The storage, readout, and modification of information is core to biological systems. The properties of an organism are primarily encoded in its genome, and how this information (genotype) maps to the morphology, physiology and development of an organism (phenotype) is a major problem of modern biology with practical consequences for personalized medicine and biotechnology as well as conceptual consequences for understanding all of biology from development to evolution. Other core principles of biology will be presented in the context of understanding information flow. May be taken pass/fail if taken in a first-year student's first year. Limited enrollment. Not offered 2023-24.